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Compare 2,511 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.
Hyatt Regency Greenville
Hyatt Regency Greenville
8.8 out of 10, Excellent, (1002)
The price is $152
$172 total
includes taxes & fees
Jul 1 - Jul 2
Cambria Hotel Greenville
Cambria Hotel Greenville
9.4 out of 10, Exceptional, (654)
The price is $135
$149 total
includes taxes & fees
Jun 9 - Jun 10
Drury Inn & Suites Greenville
Drury Inn & Suites Greenville
9.4 out of 10, Exceptional, (1003)
The price is $117
$129 total
includes taxes & fees
Jun 16 - Jun 17
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Courtyard by Marriott Greenville Downtown
Courtyard by Marriott Greenville Downtown
9.4 out of 10, Exceptional, (847)
The price is $139
$157 total
includes taxes & fees
Jun 2 - Jun 3
Hyatt Place Greenville/Downtown
Hyatt Place Greenville/Downtown
9.0 out of 10, Wonderful, (1006)
The price is $144
$163 total
includes taxes & fees
Jun 16 - Jun 17
Comfort Suites Greenville Airport
Comfort Suites Greenville Airport
9.4 out of 10, Exceptional, (761)
The price is $108
$118 total
includes taxes & fees
Jun 16 - Jun 17
Comfort Suites At WestGate Mall
Comfort Suites At WestGate Mall
8.2 out of 10, Very Good, (1003)
The price is $93
$103 total
includes taxes & fees
Jun 16 - Jun 17
Holiday Inn Express Hotel & Suites Greenville, an IHG Hotel
Holiday Inn Express Hotel & Suites Greenville, an IHG Hotel
9.0 out of 10, Wonderful, (784)
The price is $108
$121 total
includes taxes & fees
Jul 1 - Jul 2
Holiday Inn Express & Suites Greenville - Downtown, an IHG Hotel
Holiday Inn Express & Suites Greenville - Downtown, an IHG Hotel
8.6 out of 10, Excellent, (1003)
The price is $127
$140 total
includes taxes & fees
Jul 1 - Jul 2
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
9.8 out of 10, Exceptional, (279)
The price is $169
$188 total
includes taxes & fees
Jun 16 - Jun 17
Microtel Inn & Suites by Wyndham Anderson/Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
8.2 out of 10, Very Good, (1001)
The price is $80
$89 total
includes taxes & fees
Jul 1 - Jul 2
Best Western Greenville Airport Inn
Best Western Greenville Airport Inn
7.8 out of 10, Good, (1002)
The price is $74
$82 total
includes taxes & fees
Jun 2 - Jun 3
Days Inn by Wyndham Clayton
Days Inn by Wyndham Clayton
6.8 out of 10, (693)
The price is $77
$94 total
includes taxes & fees
Jun 16 - Jun 17
Baymont by Wyndham Easley/Greenville
Baymont by Wyndham Easley/Greenville
7.2 out of 10, Good, (562)
The price is $66
$74 total
includes taxes & fees
Jun 16 - Jun 17
Holiday Inn Express Brevard City Center, an IHG Hotel
Holiday Inn Express Brevard City Center, an IHG Hotel
9.2 out of 10, Wonderful, (369)
The price is $120
$134 total
includes taxes & fees
Jun 9 - Jun 10
Holiday Inn Express & Suites Clemson, an IHG Hotel
Holiday Inn Express & Suites Clemson, an IHG Hotel
9.0 out of 10, Wonderful, (781)
The price is $120
$133 total
includes taxes & fees
Jun 16 - Jun 17
Holiday Inn Express & Suites Greenville Airport, an IHG Hotel
Holiday Inn Express & Suites Greenville Airport, an IHG Hotel
8.0 out of 10, Very Good, (706)
The price is $100
$110 total
includes taxes & fees
Jun 9 - Jun 10
The Abernathy of Clemson
The Abernathy of Clemson
9.6 out of 10, Exceptional, (396)
The price is $159
$176 total
includes taxes & fees
Jun 16 - Jun 17
Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
7.0 out of 10, Good, (606)
The price is $72
$79 total
includes taxes & fees
Jun 9 - Jun 10
Quality Inn
Quality Inn
7.0 out of 10, Good, (711)
The price is $60
$66 total
includes taxes & fees
Jun 16 - Jun 17
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
3 out of top 10 points of interest in this area
5/5(654 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Stay near popular Upstate South Carolina attractions
Clemson University
5/5(410 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Recent reviews of Upstate South Carolina hotelsExpedia verified reviews
5/5 Excellent
10/10 absolutely wonderful
"The reviews I saw said how horrible it was. This place is so clean, we were greeted with kindness, the rooms were small of course but clean and reset nicely for us. The breakfast was small and quaint. The coffee was fine. The Indian decent man and woman were so sweet and offered suggestions on what to do around the area. Would definitely stay again. No bugs. The outside of the building is like a cottage. It was so cute. My marine vet husband saw it and immediately blurted out 'AWW ITS SO CUTE' in the manliest way possible haha. It was great"
A verified traveler stayed at Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
Posted 2 days ago
Hotels in Upstate South Carolina Neighborhoods
- Hotels in Greenville Downtown
- Hotels in West End
- Hotels in Green Avenue
- Hotels in Hampton-Pinckney Historic District
- Hotels in Colonel Elias Earle Historic District
- Hotels in Pettigru Street Historic District
- Hotels in Chickasaw Point
- Hotels in Cliff Ridge Colony
- Hotels in Pine Ridge Point
- Hotels in Turtlehead
- Hotels in Woodside Cotton Mill Village Historic District
- Hotels in Payne-Logan
- Hotels in Indian Oaks
- Hotels in Serenity Bay
- Hotels in Keowee Plantation
- Hotels in Central Pacolet
Stay near popular Upstate South Carolina attractions
- Hotels near Clemson University
- Hotels near Lake Keowee
- Hotels near Bon Secours Wellness Arena
- Hotels near Lake Jocassee
- Hotels near Haywood Mall
- Hotels near Falls Park on the Reedy
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Lake Hartwell
- Hotels near Greenville Convention Center
- Hotels near The Peace Center
- Hotels near Wofford College
- Hotels near Furman University
- Hotels near Fred W. Symmes Chapel
- Hotels near Devils Fork State Park
- Hotels near Anderson University
- Hotels near BMW Performance Center
- Hotels near Bob Jones University
- Hotels near Fluor Field at the West End
- Hotels near Frankie's Fun Park
- Hotels near WestGate Mall
More Hotel Options in Upstate South Carolina
- Business Hotels (144)
- Cheap Hotels (62)
- Family Hotels (155)
- Golf Hotels (95)
- Historic Hotels (76)
- Hotel Wedding Venues (51)
- Hotels & Resorts for Couples (67)
- Hotels on the Lake (65)
- Hotels with Air Conditioning (181)
- Hotels with Balconies (19)
- Hotels with Bars (62)
- Hotels with Connecting Rooms (85)
- Hotels with Free Airport Shuttle (21)
- Hotels with Free Breakfast (132)
- Hotels with Free Parking (157)
- Hotels with Free Wifi (157)
- Hotels with Hot Tubs (27)
- Hotels with Laundry Facilities (125)
- Hotels with Restaurants (164)
- Hotels with Room Service (25)
- Hotels with Suites (29)
- Hotels with a Gym (113)
- Hotels with a Pool (126)
- Hotels with a View (32)
- Hotels with an Indoor Pool (21)
- Hotels with an Outdoor Pool (125)
- Hotels with smoking rooms (21)
- Luxury Hotels (38)
- Non-Smoking Hotels (92)
- Pet-friendly Hotels (85)
- Resorts & Hotels with Spas (26)
- Romantic Hotels (42)
More Accommodation Types in Upstate South Carolina
- Vacation Homes in Upstate South Carolina (826)
- Apartments in Upstate South Carolina (145)
- Cottages in Upstate South Carolina (112)
- Cabin Rentals in Upstate South Carolina (93)
- Condo Rentals in Upstate South Carolina (63)
- Motels in Upstate South Carolina (22)
- Villas in Upstate South Carolina (9)
- Farmstay in Upstate South Carolina (8)
- RV Parks in Upstate South Carolina (7)
- B&B in Upstate South Carolina (6)
- Guest Houses in Upstate South Carolina (6)
- Aparthotels in Upstate South Carolina (5)
- Chalets in Upstate South Carolina (3)
- Lodges in Upstate South Carolina (2)
- Condo Resorts in Upstate South Carolina (1)
- Houseboats in Upstate South Carolina (1)
Upstate South Carolina Hotels by Brand
Other Hotels near Upstate South Carolina, South Carolina
- Hotels in Greenville
- Hotels in Lake Lure
- Hotels in Highlands
- Hotels in Hendersonville
- Hotels in Black Mountain
- Hotels in Rock Hill
- Hotels in North Georgia Mountains
- Hotels in Brevard
- Hotels in Franklin
- Hotels in North Carolina Mountains
- Hotels in Anderson
- Hotels in Spartanburg
- Hotels in Blue Ridge Mountains
- Hotels in Cashiers
- Hotels in Clemson
- Hotels in Clayton
- Hotels in Seneca
- Hotels in Gastonia
- Hotels in Arden
- Hotels in Greer
More Popular Hotels in South Carolina
- Sleep Inn
- Embassy Suites Greenville Golf Resort & Conference Center
- Drury Inn & Suites Greenville
- Grand Bohemian Lodge Greenville, Autograph Collection
- Quality Inn & Suites Greenville - Haywood Mall
- Comfort Suites At WestGate Mall
- Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
- Hyatt Place Greenville/Downtown
- Best Western Greenville Airport Inn
- Wingate by Wyndham - Greenville-Airport
- Hampton Inn Spartanburg-North I-85
- Best Western Spartanburg Northwest
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