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Find Resorts & Hotels with Spas in Seneca, SC

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Pick from 65 Seneca Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Beach nearby, sun loungers, beach towels
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
10.0 out of 10, Exceptional, (65)
"This was my 2nd time using the property for my company ELT (Executive Leadership Team) offsite. My team enjoyed the house and amenities. Most of our meetings were held in the screened in porch. Having the calming water views was a huge bonus. Several team members have requested we return for our July or October ELT."
The price is $910
$1,766 total
includes taxes & fees
Jun 13 - Jun 14
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Exterior
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
10.0 out of 10, Exceptional, (26)
"The house was beautiful and accommodating for our family. Was a little disappointed in the cleanliness of the house and the driveway was difficult. Enjoyed our stay!!"
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Lake Keowee/Clemson Vacation Home for Family, Friends & Football WINTER DEALS!
Exterior
Lake Keowee/Clemson Vacation Home for Family, Friends & Football WINTER DEALS!
10.0 out of 10, Exceptional, (93)
"We thoroughly enjoyed this home. Everything we could have needed was provided."
Lake Keowee/Clemson Vacation Home for Family, Friends & Football WINTER DEALS!
NEW Seneca Creek Hideaway | Hot Tub | Bar & Game Room | Close to Lakes & Clemson
Fridge, microwave, oven, stovetop
NEW Seneca Creek Hideaway | Hot Tub | Bar & Game Room | Close to Lakes & Clemson
10.0 out of 10, Exceptional, (8)
"We were busy while we were there. Caught a concert in Atlanta then a Clemson football game!!!"
NEW Seneca Creek Hideaway | Hot Tub | Bar & Game Room | Close to Lakes & Clemson
LAKE KEOWEE LAKEVIEW CABIN WITH DOCK CLOSE TO CLEMSON
Dining
LAKE KEOWEE LAKEVIEW CABIN WITH DOCK CLOSE TO CLEMSON
10.0 out of 10, Exceptional, (72)
"Stayed for a long weekend for the Clemson football game. We enjoyed our stay very clean! Host responds quickly, spacious, beautiful home! Highly recommend."
LAKE KEOWEE LAKEVIEW CABIN WITH DOCK CLOSE TO CLEMSON
Luxury on Lake Keowee - June 8th and July 27 weeks open / Summer 2025 & Football
Property grounds
Luxury on Lake Keowee - June 8th and July 27 weeks open / Summer 2025 & Football
10.0 out of 10, Exceptional, (62)
"Did not want to leave the property - activities for all age groups. We rented a boat, went white water rafting came back to the house for dinner. The entire family loved the beach and kayaking. Owners were extremely helpful."
Luxury on Lake Keowee - June 8th and July 27 weeks open / Summer 2025 & Football
Keowee Hideout at Lake Keowee
Exterior
Keowee Hideout at Lake Keowee
10.0 out of 10, Exceptional, (4)
"Great location in a quiet neighborhood/cove."
Keowee Hideout at Lake Keowee
Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
Property grounds
Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
10.0 out of 10, Exceptional, (3)
"Perfect for our graduation weekend!"
The price is $120
$367 total
includes taxes & fees
Jun 2 - Jun 3
Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
Gorgeous, newly built home with plenty of indoor and outdoor space!
Outdoor spa tub
Gorgeous, newly built home with plenty of indoor and outdoor space!
10.0 out of 10, Exceptional, (7)
"Great house with amazing views of lake. Well stocked and easy to deal with Clemson vacation rentals. Quiet neighborhood with beautiful homes. Would definitely rent again."
Gorgeous, newly built home with plenty of indoor and outdoor space!
Spacious Log Cabin on Point Lot, Private Beach, Boat and PWC Rental Available
Spacious Log Cabin on Point Lot, Private Beach, Boat and PWC Rental Available
9.8 out of 10, Exceptional, (76)
"Brought the family for an extended weekend on Keowee and thoroughly enjoyed our stay. Carter was an outstanding host and the house was perfect for everything we needed."
Spacious Log Cabin on Point Lot, Private Beach, Boat and PWC Rental Available
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Seneca Resorts & Hotels with Spas information

 

Resorts & Hotels with Spas in Seneca

65

Highest price
$910
Cheapest price
$99
Number of guest reviews
1,887
Total number of hotels in Seneca
1,490

 

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Seneca?
Hampton Inn & Suites Seneca-Clemson Area, SC is a top spa hotel featuring a pool and a 24-hour fitness center.
How many spa hotels will I find in Seneca?
Among Expedia’s 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Lake Keowee, Keowee Key Golf Course, and Lake Hartwell. If you have some spare time during your trip, you might want to check out Keowee Reservoir and Littlejohn Coliseum.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

Recent reviews of Seneca hotels
Expedia verified reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

5/5 Excellent
Fine stay
"Adequate room for our needs"
A verified traveler stayed at Hampton Inn & Suites Seneca-Clemson Area
Posted 4 days ago
Hampton Inn & Suites Seneca-Clemson Area